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Article

Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets.

Scientific reports - 15 Dec 2015

Zhang Shoudong, Zhan Xiangqiang, Xu Xiaoming, Cui Peng, Zhu Jian-Kang, Xia Yiji, Xiong Liming

Abstract excerpt

HDA6 is a RPD3-like histone deacetylase. In Arabidopsis, it mediates transgene and some endogenous target transcriptional gene silencing (TGS) via histone deacetylation and DNA methylation. Here, we characterized two hda6 mutant alleles that were recovered as second-site suppressors of the DNA demethylation mutant ros1-1. Although both alleles derepressed 35S::NPTII and RD29A::LUC in the ros1-1 background, they...

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Complementation Test

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Source

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Identifiers

PMID: 26666962
DOI: 10.1038/srep17832
PMCID: PMC4678874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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