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Article

Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis.

International journal of molecular sciences - 29 Aug 2022

Alves Raquel, Gonçalves Ana Cristina, Jorge Joana, Marques Gilberto, Ribeiro André B, Tenreiro Rita, Coucelo Margarida, Diamond Joana, Oliveiros Bárbara, Pereira Amélia, Freitas-Tavares Paulo, Almeida António M, Sarmento-Ribeiro Ana Bela

Abstract excerpt

Solute carrier (SLC) and ATP-binding cassette (ABC) transporters comprise a variety of proteins expressed on cell membranes responsible for intrusion or extrusion of substrates, respectively, including nutrients, xenobiotics, and chemotherapeutic agents. These transporters mediate the cellular disposition of tyrosine kinase inhibitors (TKIs), and their genetic variants could affect its function, potentially...

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Share to Antineoplastic Agents
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Fusion Proteins, bcr-abl

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Membrane Transport Proteins

Share to Protein Kinase Inhibitors

Share to Solute Carrier Family 22 Member 5

Source

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Identifiers

PMID: 36077209
DOI: 10.3390/ijms23179815
PMCID: PMC9456284

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