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Adaptation of CHO cells in serum‐free conditions for erythropoietin production: Application of EVOP technique for process optimization

14 Dec 2015

Abstract excerpt

Mammalian cell cultures are the preferred expression systems for the production of biopharmaceuticals requiring posttranslational processing. Usually, cell cultures are cultivated in medium supplemented with serum, which supports cell proliferation, viability, and productivity. However, due to scientific and regulatory concerns, serum-free conditions are required in recombinant protein production. Cell lines that...

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PMID: 26661088
DOI: 10.1002/bab.1468

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