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Article

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome.

Human molecular genetics - 1 Sept 2001

Ghosh T K, Packham E A, Bonser A J, Robinson T E, Cross S J, Brook J D

Abstract excerpt

Holt-Oram syndrome is caused by mutations in TBX5, a member of the T-box gene family. In order to identify DNA sequences to which the TBX5 protein binds, we have performed an in vitro binding site selection assay. We have identified an 8 bp core sequence that is part of the Brachyury consensus-binding site. We show that TBX5 binds to the full palindromic Brachyury binding site and to the half-palindrome, whereas...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11555635
DOI: 10.1093/hmg/10.18.1983

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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