Article

Early frameshift alleles of zebrafish <i>tbx5a</i> that fail to develop the heartstrings phenotype

2017-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Tbx5 is a key transcription factor for vertebrate heart and forelimb development that causes Holt-Oram syndrome when mutated in humans. The classic zebrafish mutant for tbx5a named heartstrings (hst) features recessive absence of pectoral fins and a spectrum of heart defects, most-prominently featuring the name-giving stretched heart tube. The mutation of the hst allele is a stop codon that i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 333ee1e8-e59d-5904-9a0a-5120b3323921
DOI: 10.1101/103168

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early frameshift alleles of zebrafish <i>tbx5a</i> that fail to develop the heartstrings phenotypeDOI 10.1101/103168Read

Generation of a CRISPR/Cas edited human induced pluripotent stem cell line DHMi005-A-1 carrying a patient-specific disease-causing point mutation in the TBX5 gene.Semantic proximity Read

Patient-informed CRISPR Screen Identifies FLNB as a Novel Congenital Heart Disease and Ciliopathy GeneSemantic proximity Read

Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.Semantic proximity Read

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.Semantic proximity Read

Patient-informed CRISPR screen identifies FLNB as a congenital heart disease and ciliopathy gene.Semantic proximity Read

Current advances in Holt-Oram syndrome.Semantic proximity Read

Zebrafish <i>acta1b</i> as a Candidate for Modeling Human Actin CardiomyopathiesSemantic proximity Read

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart diseaseSemantic proximity Read

TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts.Semantic proximity Read

Regulatory mutants of the <i>Tbx1</i> gene alter transcription programs of lineage determination and patterning in early mesodermSemantic proximity Read

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and DiseaseSemantic proximity Read

TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed.Semantic proximity Read