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Article

Prognostic value of cyclooxygenase-2 gene polymorphisms in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy.

Asia-Pacific journal of clinical oncology - 1 Jun 2016

Liu Lu, Zhou Fei, Ren Shengxiang, Chen Xiaoxia, Li Xuefei, Li Wei, Zhou Caicun

Abstract excerpt

AIM: Cyclooxygenase-2 (COX-2) plays an important role in cell apoptosis, angiogenesis and tumor invasion, and over-expression of COX-2 is associated with tumor development and occurrence. The aim of this study is to investigate the association between COX-2 polymorphisms and clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with first-line platinum-based chemotherapy. METHODS: A...

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PMID: 25131817
DOI: 10.1111/ajco.12258

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