Article
The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis.
PloS one - 1 Jan 2015
Rawson Renee, Anilkumar Arjun, Newbury Robert O, Bafna Vineet, Aquino Melissa, Palmquist Jacob, Hoffman Hal M, Mueller James L, Dohil Ranjan, Broide David H, Aceves Seema S
Abstract excerpt
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic antigen mediated disease associated with substantial esophageal remodeling and fibrosis. The functional TGFβ1 promoter SNP C-509 associates with renal fibrosis and asthma. The effect of TGFβ1 genotype and EoE severity or potential gene-environment interactions have not been previously reported in EoE. METHODS: Genotype at TGFβ1 C-509T and remodeling was...
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