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Article

A vocabulary of ancient peptides at the origin of folded proteins.

eLife - 14 Dec 2015

Alva Vikram, Söding Johannes, Lupas Andrei N

Abstract excerpt

The seemingly limitless diversity of proteins in nature arose from only a few thousand domain prototypes, but the origin of these themselves has remained unclear. We are pursuing the hypothesis that they arose by fusion and accretion from an ancestral set of peptides active as co-factors in RNA-dependent replication and catalysis. Should this be true, contemporary domains may still contain vestiges of such...

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Identifiers

PMID: 26653858
DOI: 10.7554/eLife.09410
PMCID: PMC4739770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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