Article
TREM2 rare variant p.R47H is not associated with Parkinson's disease.
Parkinsonism & related disorders - 1 Feb 2016
Mengel David, Thelen Mathias, Balzer-Geldsetzer Monika, Söling Charlotte, Bach Jan-Philipp, Schaeffer Eva, Herold Christine, Becker Tim, Liepelt Inga, Becker Julian, Riedel-Heller Steffi, Scherer Martin, Jessen Frank, Maier Wolfgang, Dodel Richard, Ramirez Alfredo
Abstract excerpt
Variant p.R47H of triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with Parkinson's disease (PD). We screened this TREM2-variant in 821 PD patients including 261 demented PD patients (PDD) and in healthy controls (n = 919). Neither the entire PD nor the small PDD sample was associated with p.R47H.
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