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Article

Malignant pheochromocytomas/paragangliomas harbor mutations in transport and cell adhesion genes.

International journal of cancer - 1 May 2016

Wilzén Annica, Rehammar Anna, Muth Andreas, Nilsson Ola, Tešan Tomić Tajana, Wängberg Bo, Kristiansson Erik, Abel Frida

Abstract excerpt

One out of ten patients with pheochromocytoma (PCC) and paraganglioma (PGL) develop malignant disease. Today there are no reliable pathological methods to predict malignancy at the time of diagnosis. Tumors harboring mutations in the succinate dehydrogenase subunit B (SDHB) gene often metastasize but the sequential genetic events resulting in malignant progression are not fully understood. The aim of this study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26650627
DOI: 10.1002/ijc.29957

Genes

MYCN
SDHB
VCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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