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Article

MYO5B mutations in pheochromocytoma/paraganglioma promote cancer progression

8 Jun 2020

Abstract excerpt

Identification of additional cancer-associated genes and secondary mutations driving the metastatic progression in pheochromocytoma and paraganglioma (PPGL) is important for subtyping, and may provide optimization of therapeutic regimens. We recently reported novel recurrent nonsynonymous mutations in the MYO5B gene in metastatic PPGL. Here, we explored the functional impact of these MYO5B mutations, and analyzed...

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PMID: 32511227
DOI: 10.1371/journal.pgen.1008803

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