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The Genetic Landscape of Pheochromocytomas and Paragangliomas: Somatic Mutations Take Center Stage

1 Jul 2013

Abstract excerpt

The neural crest-derived, catecholamine-secreting tumors, pheochromocytomas, and their related extra-adrenal counterparts, paragangliomas, have gone through what amounts to a genetic revolution over the past decade (1). From scant knowledge of the genetic basis of a small fraction of clearly syndromic cases in the mid-1990s to the current detection of a germline driver mutation in nearly half of the cases, the...

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Identifiers

PMID: 23837189
DOI: 10.1210/jc.2013-2191

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