Article
Comprehensive Genetic Study of Malignant Cervical Paraganglioma.
International journal of molecular sciences - 4 May 2023
Snezhkina Anastasiya, Pavlov Vladislav, Fedorova Maria, Kalinin Dmitry, Pudova Elena, Kobelyatskaya Anastasiya, Bakhtogarimov Ildar, Krasnov George, Kudryavtseva Anna
Abstract excerpt
Malignant middle ear paraganglioma (MEPGL) is an exceedingly rare tumor of the neuroendocrine system. In general, MEPGLs represent as slow growing and hypervascularized benign neoplasms. The genetic basis of MEPGL tumorigenesis has been poorly investigated. We report a case of malignant MEPGL accompanied by the comprehensive genetic analysis of the primary tumor and metastasis. Based on whole-exome sequencing...
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