Article
Treatment responses to antiangiogenetic therapy and chemotherapy in nonsecreting paraganglioma (PGL4) of urinary bladder with SDHB mutation: A case report.
Medicine - 1 Jul 2018
Stigliano Antonio, Lardo Pina, Cerquetti Lidia, Aschelter Anna Maria, Matarazzo Iolanda, Capriotti Gabriela, Schiavi Francesca, Marchetti Paolo, Nardone Maria Rosaria, Petrangeli Elisa, Toscano Vincenzo
Abstract excerpt
INTRODUCTION: Paraganglioma (PGL) is a rare neuroendocrine tumor. Currently, the malignancy is defined as the presence of metastatic spread at presentation or during follow-up. Several gene mutations are listed in the pathogenesis of PGL, among which succinate dehydrogenase (SDHX), particularly the SDHB isoform, is the main gene involved in malignancy. A 55-year-old male without evidence of catecholamine...
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