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Article

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

26 Apr 2016

Abstract excerpt

Targeting a host factor essential for the replication of different viruses but not for the cells offers a higher genetic barrier to the development of resistance, may simplify therapy regimens for coinfections, and facilitates management of emerging viral diseases. DEAD-box polypeptide 3 (DDX3) is a human host factor required for the replication of several DNA and RNA viruses, including some of the most...

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PMID: 27118832
DOI: 10.1073/pnas.1522987113

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