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Article

Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses.

Journal of medicinal chemistry - 10 Sept 2020

Riva Valentina, Garbelli Anna, Brai Annalaura, Casiraghi Federica, Fazi Roberta, Trivisani Claudia I, Boccuto Adele, Saladini Francesco, Vicenti Ilaria, Martelli Francesco, Zazzi Maurizio, Giannecchini Simone, Dreassi Elena, Botta Maurizio, Maga Giovanni

Abstract excerpt

Emerging viruses like dengue, West Nile, chikungunya, and Zika can cause widespread viral epidemics. Developing novel drugs or vaccines against specific targets for each virus is a difficult task. As obligate parasites, all viruses exploit common cellular pathways, providing the possibility to develop broad-spectrum antiviral agents targeting host factors. The human DEAD-box RNA helicase DDX3X is an essential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32787106
DOI: 10.1021/acs.jmedchem.0c01039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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