Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geometry Dynamics of α -Helices in Different Class I Major Histocompatibility Complexes.

Journal of immunology research - 1 Jan 2015

Ribarics Reiner, Kenn Michael, Karch Rudolf, Ilieva Nevena, Schreiner Wolfgang

Abstract excerpt

MHC α-helices form the antigen-binding cleft and are of particular interest for immunological reactions. To monitor these helices in molecular dynamics simulations, we applied a parsimonious fragment-fitting method to trace the axes of the α-helices. Each resulting axis was fitted by polynomials in a least-squares sense and the curvature integral was computed. To find the appropriate polynomial degree, the method...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to HLA-B27 Antigen
Share to Least-Squares Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Peptides

Share to Protein Interaction Domains and Motifs

Share to Protein Structure, Secondary

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 26649324
DOI: 10.1155/2015/173593
PMCID: PMC4651647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geometry Dynamics of α -Helices in Different Class I Major Histocompatibility Complexes.PMID 26649324Read ↗

Molecular Dynamics Analysis of Self and Microbial Peptides Bound to HLA-B Protein: A Multi-Parameter FrameworkSemantic proximity Read ↗

Relative Movements of Domains in Large Molecules of the Immune System.Semantic proximity Read ↗

Unraveling the Allosteric Communication Mechanisms in T-Cell Receptor–Peptide-Loaded Major Histocompatibility Complex Dynamics Using Molecular Dynamics Simulations: An Approach Based on Dynamic Cross Correlation Maps and Residue Interaction Energy CalculationsSemantic proximity Read ↗

Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles.Semantic proximity Read ↗

How T cell receptors interact with peptide-MHCs: a multiple steered molecular dynamics study.Semantic proximity Read ↗

Mechanical design of the third FnIII domain of tenascin-C.Semantic proximity Read ↗

Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar.Semantic proximity Read ↗

Detailed description of an alpha helix-->pi bulge transition detected by molecular dynamics simulations of the p185c-erbB2 V659G transmembrane domain.Semantic proximity Read ↗

An Immunodominant Epitope of Myelin Basic Protein Is an Amphipathic α-HelixSemantic proximity Read ↗

Review of nonlinear analysis of proteins through recurrence quantification.Semantic proximity Read ↗

Two structural states of complexes of peptide and class II major histocompatibility complex revealed by photoaffinity-labeled peptides.Semantic proximity Read ↗

Correlated motions and propagation of the effect of a local conformational change in the transmembrane helix of the c-erb B2 encoded protein and its V659E mutant, studied by molecular dynamics simulations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.