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Article

RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action.

Oncotarget - 21 Jun 2016

Masliah-Planchon Julien, Garinet Simon, Pasmant Eric

Abstract excerpt

The highly conserved RAS-mitogen activated protein kinase (MAPK) signaling pathway is involved in a wide range of cellular processes including differentiation, proliferation, and survival. Somatic mutations in genes encoding RAS-MAPK components frequently occur in many tumors, making the RAS-MAPK a critical pathway in human cancer. Since the pioneering study reporting that let-7 miRNA acted as tumor suppressor by...

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Share to Carcinogenesis
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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to MAP Kinase Signaling System

Share to MicroRNAs

Share to ras Proteins

Source

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Identifiers

PMID: 26646588
DOI: 10.18632/oncotarget.6476
PMCID: PMC5122439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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