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Article

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

1 Jan 2012

Abstract excerpt

INTRODUCTION: The MAPK pathway comprises several key signaling components and phosphorylation events that play a role in tumorigenesis. These activated kinases transmit extracellular signals that regulate cell growth, differentiation, proliferation, apoptosis and migration functions. Alteration of the RAS-RAF-MEK-ERK-MAPK (RAS-MAPK) pathway has been reported in human cancer as a result of abnormal activation of...

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PMID: 22239440
DOI: 10.1517/14728222.2011.645805

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