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Article

Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain.

Current issues in molecular biology - 7 Jun 2021

Bonnin Philippe, Vitalis Tania, Schwendimann Leslie, Boutigny Alexandre, Mohamedi Nassim, Besson Valérie C, Charriaut-Marlangue Christiane

Abstract excerpt

The poly(ADP-ribose) polymerase inhibitor PJ34 has recently been reported to increase cerebral blood flow, via the endothelial NO synthase, in the naive mouse brain throughout life. We addressed here the benefits of PJ34 after neonatal ischemia on hemodynamics and components of the neurovascular unit including the blood-brain barrier (BBB), microglia, and astrocytes. Nine-day-old mice were subjected to permanent...

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Identifiers

PMID: 34200155
DOI: 10.3390/cimb43010025
PMCID: PMC8929080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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