Article
Pharmacokinetics and pharmacodynamics of mycophenolic acid in Nagase analbuminemic rats: Evaluation of protein binding effects using the modeling and simulation approach.
Drug metabolism and pharmacokinetics - 1 Dec 2015
Yoshimura Kazuaki, Yano Ikuko, Kawanishi Misaki, Nakagawa Shunsaku, Yonezawa Atsushi, Matsubara Kazuo
Abstract excerpt
This study aimed to examine the pharmacokinetics and pharmacodynamics of mycophenolic acid (MPA) in Nagase analbuminemic rats (NARs) to evaluate the effect of protein binding on the associated inosine-5'-monophosphate dehydrogenase (IMPDH) activity. Free fractions of MPA in the control rats and NARs were 2.09 and 24.8%, respectively. Pharmacokinetic and pharmacodynamic parameters simultaneously obtained by the...
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