Article
Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients.
Clinical pharmacology and therapeutics - 1 Nov 2006
Naesens Maarten, Kuypers Dirk R J, Streit Frank, Armstrong Victor W, Oellerich Michael, Verbeke Kristin, Vanrenterghem Yves
Abstract excerpt
BACKGROUND: Exposure to mycophenolic acid (MPA) and its main metabolites (MPA 7-O-glucuronide [MPAG] and MPA acyl-glucuronide [AcMPAG]) is characterized by a large interindividual and intraindividual variability, resulting in part from variability in glucuronidation (via uridine diphosphate-glucuronosyltransferase isoforms) and excretion via multidrug resistance-associated protein 2 (MRP2). It can be hypothesized...
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