Article
Helicobacter pylori stores nickel to aid its host colonization.
Infection and immunity - 1 Feb 2013
Benoit Stéphane L, Miller Erica F, Maier Robert J
Abstract excerpt
The transition metal nickel (Ni) is critical for the pathogenicity of Helicobacter pylori. Indeed the element is a required component of two enzymes, hydrogenase and urease, that have been shown to be important for in vivo colonization of the host gastric mucosa. Urease accounts for up to 10% of the total cellular H. pylori protein content, and therefore the bacterial Ni demand is very high. H. pylori possess two...
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