Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic HypA zinc site is essential for acid viability and proper urease maturation in Helicobacter pylori.

Metallomics : integrated biometal science - 1 Apr 2015

Johnson Ryan C, Hu Heidi Q, Merrell D Scott, Maroney Michael J

Abstract excerpt

Helicobacter pylori requires urease activity in order to survive in the acid environment of the human stomach. Urease is regulated in part by nickelation, a process that requires the HypA protein, which is a putative nickel metallochaperone that is generally associated with hydrogenase maturation. However, in H. pylori, HypA plays a dual role. In addition to an N-terminal nickel binding site, HypA proteins also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori
Share to Hydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Spectroscopy

Share to Nickel

Share to Stomach

Share to Urease

Source

Open in PubMed Open full text

Identifiers

PMID: 25608738
DOI: 10.1039/c4mt00306c
PMCID: PMC4390472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic HypA zinc site is essential for acid viability and proper urease maturation in Helicobacter pylori.PMID 25608738Read ↗

Nickel Ligation of the N-Terminal Amine of HypA Is Required for Urease Maturation in Helicobacter pylori.Semantic proximity Read ↗

Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori.Semantic proximity Read ↗

Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for ColonizationSemantic proximity Read ↗

Nickel trafficking system responsible for urease maturation inHelicobacter pyloriSemantic proximity Read ↗

Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pyloriSemantic proximity Read ↗

Characterization in Helicobacter pylori of a Nickel Transporter Essential for Colonization That Was Acquired during Evolution by Gastric Helicobacter SpeciesSemantic proximity Read ↗

Nickel translocation between metallochaperones HypA and UreE in Helicobacter pyloriSemantic proximity Read ↗

Roles of His-rich hpn and hpn-like proteins in Helicobacter pylori nickel physiology.Semantic proximity Read ↗

Nickel enzyme maturation in Helicobacter hepaticus: roles of accessory proteins in hydrogenase and urease activities.Semantic proximity Read ↗

The <i>Helicobacter pylori</i> GroES Cochaperonin HspA Functions as a Specialized Nickel Chaperone and Sequestration Protein through Its Unique C-Terminal ExtensionSemantic proximity Read ↗

Helicobacter pylori stores nickel to aid its host colonization.Semantic proximity Read ↗

Interaction between hydrogenase maturation factors HypA and HypB is required for [NiFe]-hydrogenase maturation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.