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Article

The effect of in vitro consecutive passages and culture medium on the genetic variations in BCG Pasteur 1173P2 vaccine.

PloS one - 1 Jan 2023

Asadian Mahla, Hassanzadeh Seyed Mehdi, Safarchi Azadeh, Douraghi Masoumeh

Abstract excerpt

Since the introduction of the Bacillus Calmette-Guérin (BCG) vaccine, the genomes of vaccine strains have undergone variations due to repeated passages in different laboratories and vaccine production facilities. Genetic variations have been considered as one of the effective factors in the BCG variable protective efficacy. Consecutive subcultures have been shown to play an essential role in causing genetic...

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Identifiers

PMID: 36689397
DOI: 10.1371/journal.pone.0280294
PMCID: PMC9870133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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