Article
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer.
Genetics and molecular research : GMR - 25 Nov 2015
Rodrigues P R S, Maia L L, Santos M, Peterle G T, Alves L U, Takamori J T, Souza R P, Barbosa W M, Mercante A M C, Nunes F D, Carvalho M B, Tajara E H, Louro I D, Silva-Conforti A M A
Abstract excerpt
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with...
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