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Article

Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: a case control study.

BMC cancer - 18 Nov 2008

Okobia Michael N, Bunker Clareann H, Garte Seymour J, Zmuda Joseph M, Ezeome Emmanuel R, Anyanwu Stanley N, Uche Emmanuel E, Kuller Lewis H, Ferrell Robert E, Taioli Emanuela

Abstract excerpt

BACKGROUND: Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin receptor have recently been implicated in processes leading to breast cancer initiation and progression in animal models and humans. An A to G transition mutation in codon 223 in exon 6 of the leptin...

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Identifiers

PMID: 19017403
DOI: 10.1186/1471-2407-8-338
PMCID: PMC2613914

Genes

LEPR

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