Article
Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer.
Journal of cancer research and clinical oncology - 1 Apr 2009
Yapijakis Christos, Kechagiadakis Michael, Nkenke Emeka, Serefoglou Zoe, Avgoustidis Dimitrios, Vylliotis Antonis, Perrea Despina, Neukam Friedrich W, Patsouris Efstratios, Vairaktaris Eleftherios
Abstract excerpt
PURPOSE: We investigated the possible association of DNA polymorphisms -2548G/A and Q223R in the leptin (LEP) and leptin receptor (LEPR) genes, respectively, which both affect the amount of circulating cytokine-type hormone leptin, with risk for development of oral cancer. METHODS: Polymerase chain reaction-based restriction analysis was performed in DNA samples of 150 patients with oral squamous cell carcinoma...
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