Article

Alterations in background ECoG activity and behavioral deficits in a mouse model of CHD2-related developmental delay

2025-03-18

Abstract excerpt

Heterozygous loss of function mutations in the CHD2 gene, encoding for chromodomain helicase DNA-binding protein 2, are associated with severe childhood-onset epilepsy, global developmental delay, and autistic features. Here, we characterized the behavioral and epileptic phenotypes of a mouse model harboring a frameshift truncating mutation in the Chd2 gene ( Chd2 WT / m and Chd2 m/m mice). Genetic backgroun...

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Literature Corpus work: fef001ce-7b92-5ef7-8d63-44bac17238c2
DOI: 10.1101/2025.03.18.643778

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