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Aligned Nanofibers Direct Human Dermal Fibroblasts to Tenogenic Phenotype In Vitro and Enhance Tendon Regeneration In Vivo

13 Apr 2016

Abstract excerpt

AIM: To explore the effect of aligned nanofibers on inducing tenogenic phenotype of human dermal fibroblasts (hDFs) in vitro and on inducing de novo tendon regeneration in vivo. MATERIALS & METHODS: Random and aligned nanofibers were electrospun, seeded with hDFs and cultured in vitro, and in vivo implanted without cell seeding to bridge segmental defect of rat Achilles tendon. RESULTS: In vitro, the well-aligned...

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PMID: 27074092
DOI: 10.2217/nnm.16.24

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