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Article

Tendon-Derived Biomimetic Surface Topographies Induce Phenotypic Maintenance of Tenocytes In Vitro.

Tissue engineering. Part A - 1 Aug 2021

Dede Eren Aysegul, Vasilevich Aliaksey, Eren E Deniz, Sudarsanam Phanikrishna, Tuvshindorj Urandelger, de Boer Jan, Foolen Jasper

Abstract excerpt

The tenocyte niche contains biochemical and biophysical signals that are needed for tendon homeostasis. The tenocyte phenotype is correlated with cell shape in vivo and in vitro, and shape-modifying cues are needed for tenocyte phenotypical maintenance. Indeed, cell shape changes from elongated to spread when cultured on a flat surface, and rat tenocytes lose the expression of phenotypical markers throughout five...

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Identifiers

PMID: 33045937
DOI: 10.1089/ten.TEA.2020.0249

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