Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination.

The Journal of biological chemistry - 26 Feb 2016

Takasugi Toshiyuki, Minegishi Seiji, Asada Akiko, Saito Taro, Kawahara Hiroyuki, Hisanaga Shin-ichi

Abstract excerpt

Cdk5 is a versatile protein kinase that is involved in various neuronal activities, such as the migration of newborn neurons, neurite outgrowth, synaptic regulation, and neurodegenerative diseases. Cdk5 requires the p35 regulatory subunit for activation. Because Cdk5 is more abundantly expressed in neurons compared with p35, the p35 protein levels determine the kinase activity of Cdk5. p35 is a protein with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase 5
Share to Half-Life

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoylation

Share to Mice, Inbred ICR

Share to Phosphotransferases

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 26631721
DOI: 10.1074/jbc.M115.692871
PMCID: PMC4813488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination.PMID 26631721Read ↗

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseSemantic proximity Read ↗

CDK5: A Unique CDK and Its Multiple Roles in the Nervous SystemSemantic proximity Read ↗

A kinase of many talents: non-neuronal functions of CDK5 in development and diseaseSemantic proximity Read ↗

A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypesSemantic proximity Read ↗

Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3: Potential Functions and Implications for Development and DiseaseSemantic proximity Read ↗

CDK5: an oncogene or an anti-oncogene: location location locationSemantic proximity Read ↗

CDK5 activator protein p25 preferentially binds and activates GSK3βSemantic proximity Read ↗

Emerging Roles of Ubiquitin-Specific Protease 25 in DiseasesSemantic proximity Read ↗

Cdk5: a multifaceted kinase in neurodegenerative diseasesSemantic proximity Read ↗

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.Semantic proximity Read ↗

Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.Semantic proximity Read ↗

Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.