Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK5: an oncogene or an anti-oncogene: location location location

23 Nov 2023

Abstract excerpt

Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally linked to cancer of many origins. This review focuses on the molecular mechanisms by which CDK5 recruits diverse tissue-specific substrates to elicit distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37993880
DOI: 10.1186/s12943-023-01895-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK5: an oncogene or an anti-oncogene: location location locationPMID 37993880Read ↗

A kinase of many talents: non-neuronal functions of CDK5 in development and diseaseSemantic proximity Read ↗

CDK5: A Unique CDK and Its Multiple Roles in the Nervous SystemSemantic proximity Read ↗

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseSemantic proximity Read ↗

Cdk5: a multifaceted kinase in neurodegenerative diseasesSemantic proximity Read ↗

CDK5: Insights into its roles in diseasesSemantic proximity Read ↗

Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neuronsSemantic proximity Read ↗

Cdk5 in Oncology: Recent Advances and Future ProspectsSemantic proximity Read ↗

The Structural Perspective on CDK5Semantic proximity Read ↗

CDK5 involvement in cancer and in the tumor microenvironmentSemantic proximity Read ↗

Cdk5: mediator of neuronal death and survivalSemantic proximity Read ↗

CDK5 Functions as a Tumor Promoter in Human Lung CancerSemantic proximity Read ↗

An Unusual Member of the Cdk Family: Cdk5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.