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Article

Diminishing striatal activation across adolescent development during reward anticipation in offspring of schizophrenia patients.

Schizophrenia research - 1 Jan 2016

Vink Matthijs, de Leeuw Max, Pouwels Ruby, van den Munkhof Hanna E, Kahn René S, Hillegers Manon

Abstract excerpt

Schizophrenia is a severe psychiatric disorder associated with impaired fronto-striatal functioning. Similar deficits are observed in unaffected siblings of patients, indicating that these deficits are linked to a familial risk for the disorder. Fronto-striatal deficits may arise during adolescence and precede clinical manifestation of the disorder. However, the development of the fronto-striatal network in...

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Identifiers

PMID: 26631365
DOI: 10.1016/j.schres.2015.11.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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