Article
Frequency and Spectrum of MED12 Exon 2 Mutations in Multiple Versus Solitary Uterine Leiomyomas From Russian Patients.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Nov 2016
Osinovskaya Natalia S, Malysheva Olga V, Shved Natalia Yu, Ivashchenko Tatyana E, Sultanov Iskender Yu, Efimova Olga A, Yarmolinskaya Maria I, Bezhenar Vitaly F, Baranov Vladislav S
Abstract excerpt
Uterine leiomyomas (ULs) are common benign tumors affecting women of different ethnicities. A large proportion of UL has mutations in MED12. Multiple and solitary ULs usually manifest with different severities, suggesting that their origin and growth pattern may be driven by different molecular mechanisms. Here, we compared the frequency and the spectrum of MED12 exon 2 mutations between multiple (n=82) and...
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