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Article

Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.

Nature genetics - 1 Dec 2015

Moon Diane H, Segal Matthew, Boyraz Baris, Guinan Eva, Hofmann Inga, Cahan Patrick, Tai Albert K, Agarwal Suneet

Abstract excerpt

Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita, but how PARN deficiency impairs telomere maintenance is unclear. Here, using somatic cells and induced pluripotent stem cells (iPSCs) from patients with dyskeratosis congenita with PARN mutations, we show that PARN is required for the 3'-end...

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Source

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Identifiers

PMID: 26482878
DOI: 10.1038/ng.3423
PMCID: PMC4791094

Genes

PARN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.PMID 26482878Read ↗

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PARN Modulates Y RNA Stability and Its 3'-End Formation.Semantic proximity Read ↗

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Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out modelsSemantic proximity Read ↗

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