Article
The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma.
Oncotarget - 12 Jan 2016
Passaro Carmela, Borriello Francesco, Vastolo Viviana, Di Somma Sarah, Scamardella Eloise, Gigantino Vincenzo, Franco Renato, Marone Gianni, Portella Giuseppe
Abstract excerpt
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed. We have previously shown that the oncolytic adenovirus dl922-947 induces ATC cell death in vitro and tumor regression in vivo. However, the impact of dl922-947 on the pro-tumorigenic ATC...
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