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Article

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2014

Wennerberg Erik, Pfefferle Aline, Ekblad Lars, Yoshimoto Yuya, Kremer Veronika, Kaminskyy Vitaliy O, Juhlin C Christofer, Höög Anders, Bodin Inger, Svjatoha Vitalijs, Larsson Catharina, Zedenius Jan, Wennerberg Johan, Lundqvist Andreas

Abstract excerpt

PURPOSE: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive forms of cancer with no curative therapies available. To date, strategies to target ATC by immunotherapy have not been evaluated. We investigated whether ATC would be a suitable target for natural killer (NK) cell-based immunotherapy. EXPERIMENTAL DESIGN: We first established seven new cell lines from ATC tumors, three from papillary...

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Topics

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Share to Antibodies, Blocking
Share to Chemokine CXCL10

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Dinoprostone

Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Receptors, CXCR3

Share to Thyroid Carcinoma, Anaplastic

Share to TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 25212604
DOI: 10.1158/1078-0432.CCR-14-0291

Genes

CXCR3
ULBP2
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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