Article
Reimagining the Therapeutic Approach for Anaplastic Thyroid Cancer: The Roadmap to a Cure.
Thyroid : official journal of the American Thyroid Association - 1 May 2025
Cabanillas Maria E, Akhave Neal, Banuchi Victoria, Busaidy Naifa, Dadu Ramona, Ferrarotto Renata, Gunn Gary B, Hamidi Sarah, Hofmann Marie-Claude, Hosseini S Mohsen, Iyer Priyanka C, Lai Stephen Y, Lee Anna, Maniakas Anastasios, Ning Matthew S, Spiotto Michael, Wang Jennifer R, Williams Michelle D, Zafereo Mark
Abstract excerpt
Background: Anaplastic thyroid cancer (ATC) is an aggressive cancer that leads to rapid death if left untreated. However, recent advances in ATC treatment have dramatically changed the prognosis in a select group of patients with BRAFV600E mutations. In these patients, BRAF/MEK inhibitors have been shown to dramatically and rapidly shrink tumors. Yet, these responses are short-lived unless additional treatment...
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