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Article

Surface engineering of oncolytic adenovirus for a combination of immune checkpoint blockade and virotherapy

1 Jan 2021

Abstract excerpt

Selective oncolytic effects with oncolytic adenovirus led to an up-regulated expression of PD-L1 in the tumor microenvironment, turning immunologically 'cold' tumors into immunologically 'hot' tumors, presenting more targets for further enhanced target delivery. Notably, PD1-BCMNs@OA could effectively activate tumor-infiltrating T cells and elicit a strong anti-tumor immune response. Thus, PD1-BCMNs@OA may...

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PMID: 34751685
DOI: 10.1039/d1bm00928a

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