Article
Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation.
Mediators of inflammation - 1 Jan 2016
Rotondi Mario, Coperchini Francesca, Awwad Oriana, Pignatti Patrizia, Di Buduo Christian A, Abbonante Vittorio, Magri Flavia, Balduini Alessandra, Chiovato Luca
Abstract excerpt
CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harboring RET/PTC rearrangement and BRAF V600e mutation, resp.). Cells were incubated with IFNγ (1, 10,...
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