Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.

Journal of molecular biology - 18 Aug 2006

Goettsch Sandra, Badea Rodica A, Mueller Jonathan W, Wotzlaw Christoph, Schoelermann Beate, Schulz Lars, Rabiller Matthias, Bayer Peter, Hartmann-Fatu Cristina

Abstract excerpt

TPST1 is a human tyrosylprotein sulfotransferase that uses 3'phosphoadenosine-5'phosphosulfate (PAPS) to transfer the sulfate moiety to proteins predominantly designated for secretion. To achieve a general understanding of the cellular role of human tyrosine-directed sulfotransferases, we investigated targeting, structure and posttranslational modification of TPST1. Golgi localisation of the enzyme in COS-7 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oligosaccharides
Share to Asparagine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Autoantigens

Share to Fluorescence Resonance Energy Transfer

Share to Glycosylation

Share to Golgi Apparatus

Share to Intracellular Membranes

Share to Sulfotransferases

Source

Identifiers

PMID: 16859706
DOI: 10.1016/j.jmb.2006.06.023

Genes

TPST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.PMID 16859706Read ↗

A bespoke analytical workflow for the confident identification of sulfopeptides and their discrimination from phosphopeptidesSemantic proximity Read ↗

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitorsSemantic proximity Read ↗

Tyrosylprotein Sulfotransferase-2 Expression Is Required for Sulfation of RNase 9 and Mfge8 in VivoSemantic proximity Read ↗

Molecular Cloning and Expression of Human and Mouse Tyrosylprotein Sulfotransferase-2 and a Tyrosylprotein Sulfotransferase Homologue in Caenorhabditis elegansSemantic proximity Read ↗

Cell-based analysis of structure-function activity of threonine aspartase 1.Semantic proximity Read ↗

Functional genetic encoding of sulfotyrosine in mammalian cellsSemantic proximity Read ↗

New Structural Insights into the Function of the Catalytically Active Human Taspase1Semantic proximity Read ↗

Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatasesSemantic proximity Read ↗

A non-Golgi alpha 1,2-fucosyltransferase that modifies Skp1 in the cytoplasm of Dictyostelium.Semantic proximity Read ↗

Searching for Sulfotyrosines (sY) in a HA(pY)STACKSemantic proximity Read ↗

Potential for the Terminal SKP1 Glycosyltransferase to Exert Non-Enzymatic Control of SKP1 in Toxoplasma gondiiSemantic proximity Read ↗

Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.