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Article

Unique Autoantibody Epitopes in an Immunodominant Region of Thyroid Peroxidase

1 Mar 1996

Abstract excerpt

To define the autoantibody epitopes in amino acids 513-633 of thyroid peroxidase (TPO), a region frequently recognized in thyroiditis, cDNA sequences coding for peptide fragments of this region were amplified and ligated into pMalcRI and pGEX vectors for expression as recombinant fusion proteins. Western blots and enzyme-linked immunosorbent assay were then used to examine the reactivity in sera from 45...

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PMID: 8617771
DOI: 10.1074/jbc.271.9.4966

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