Article
Association of Apolipoprotein A1 Gene Polymorphisms with Serum Lipid Spectrum in Adolescents in East Siberia.
Bulletin of experimental biology and medicine - 1 Dec 2015
Bairova T A, Kalyuzhnaya O V, Dolgikh V V, Trukhin A A, Pervushina O A, Darenskaya M A, Kolesnikova L I, Kolesnikov S I
Abstract excerpt
We studied the incidence of genotypes of polymorphic alleles (-75)G>A and (+83)C>T of apolipoprotein A1 gene in healthy Russian adolescents, residents of East Siberia. Genotyping was carried out by PCR with subsequent restriction fragment length polymorphism analysis. The incidence of allele (-75)A was 22.5%, of allele (+83)T - 7.3%. Association of allele (-75) A with high blood cholesterol level was revealed.
Topics
- Adolescent
- Alleles
- Apolipoprotein A-I
- Child
- Cholesterol
- Female
- Genotype
- Humans
- Lipids
- Male
- Polymorphism, Genetic