Article
Association of Apolipoprotein A1 Gene Polymorphisms with Serum Lipid Spectrum in Adolescents in East Siberia.
Bulletin of experimental biology and medicine - 1 Dec 2015
Bairova T A, Kalyuzhnaya O V, Dolgikh V V, Trukhin A A, Pervushina O A, Darenskaya M A, Kolesnikova L I, Kolesnikov S I
Abstract excerpt
We studied the incidence of genotypes of polymorphic alleles (-75)G>A and (+83)C>T of apolipoprotein A1 gene in healthy Russian adolescents, residents of East Siberia. Genotyping was carried out by PCR with subsequent restriction fragment length polymorphism analysis. The incidence of allele (-75)A was 22.5%, of allele (+83)T - 7.3%. Association of allele (-75) A with high blood cholesterol level was revealed.
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