Article
Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity.
Clinical and experimental medicine - 1 Dec 2009
Chen Elizabeth Suchi, Mazzotti Diego Robles, Furuya Tatiane Katsue, Cendoroglo Maysa Seabra, Ramos Luiz Roberto, Araujo Lara Quirino, Burbano Rommel Rodriguez, de Arruda Cardoso Smith Marília
Abstract excerpt
Several polymorphisms in apolipoprotein A1 (APOA1) gene have been associated with metabolic diseases. Increased transcription efficiency was observed in -75A allele carriers compared to -75G allele homozygotes. +83C allele was associated with higher body mass index and waist-to-hip ratio in type II diabetes subjects. -75G/A and +83C/T polymorphisms were analyzed by RFLP-PCR in 334 individuals from a Brazilian...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Apolipoprotein A-I
- Body Mass Index
- Brazil
- Cardiovascular Diseases
- Cholesterol
- Cohort Studies
- Female
- Gene Frequency
- Haplotypes
- Humans
- Hypertension