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Article

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.

Oncogene - 1 Mar 2018

Rasheed Suhail Ahmed Kabeer, Leong Hui Sun, Lakshmanan Manikandan, Raju Anandhkumar, Dadlani Dhivya, Chong Fui-Teen, Shannon Nicholas B, Rajarethinam Ravisankar, Skanthakumar Thakshayeni, Tan Ern Yu, Hwang Jacqueline Siok Gek, Lim Kok Hing, Tan Daniel Shao-Weng, Ceppi Paolo, Wang Mei, Tergaonkar Vinay, Casey Patrick J, Iyer N Gopalakrishna

Abstract excerpt

Treatment failure in solid tumors occurs due to the survival of specific subpopulations of cells that possess tumor-initiating (TIC) phenotypes. Studies have implicated G protein-coupled-receptors (GPCRs) in cancer progression and the acquisition of TIC phenotypes. Many of the implicated GPCRs signal through the G protein GNA13. In this study, we demonstrate that GNA13 is upregulated in many solid tumors and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, G12-G13

Share to Mice, Inbred NOD

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Share to Squamous Cell Carcinoma of Head and Neck

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Source

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Identifiers

PMID: 29255247
DOI: 10.1038/s41388-017-0038-6
PMCID: PMC6168473

Genes

GNA13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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