Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line

Abstract excerpt

Mevalonic aciduria (MA, OMIM #610377), a rare autosomal recessive disease caused by mutations affecting an enzyme of the cholesterol pathway, represents the most severe form of a periodic fever called mevalonate kinase deficiency. 1 MA patients show recurrent fever episodes with associated inflammatory symptoms, severe neurologic impairments or death in early childhood. 2

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