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Article

Engineering Cel7A carbohydrate binding module and linker for reduced lignin inhibition.

Biotechnology and bioengineering - 1 Jun 2016

Strobel Kathryn L, Pfeiffer Katherine A, Blanch Harvey W, Clark Douglas S

Abstract excerpt

Non-productive binding of cellulases to lignin inhibits enzymatic hydrolysis of biomass, increasing enzyme requirements and the cost of biofuels. This study used site-directed mutagenesis of the Trichoderma Cel7A carbohydrate binding module (CBM) and linker to investigate the mechanisms of adsorption to lignin and engineer a cellulase with increased binding specificity for cellulose. CBM mutations that added...

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Identifiers

PMID: 26616493
DOI: 10.1002/bit.25889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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