Article
Identification of amino acids responsible for processivity in a Family 1 carbohydrate-binding module from a fungal cellulase.
The journal of physical chemistry. B - 28 Jan 2010
Beckham Gregg T, Matthews James F, Bomble Yannick J, Bu Lintao, Adney William S, Himmel Michael E, Nimlos Mark R, Crowley Michael F
Abstract excerpt
We probe the molecular-level behavior of the Family 1 carbohydrate-binding module (CBM) from a commonly studied fungal cellulase, the Family 7 cellobiohydrolase (Cel7A) from Trichoderma reesei, on the hydrophobic face of crystalline cellulose. With a fully atomistic model, we predict that the CBM alone exhibits regions of thermodynamic stability along a cellulose chain corresponding to a cellobiose unit, which is...
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