Article
MUC20 promotes aggressive phenotypes of epithelial ovarian cancer cells via activation of the integrin β1 pathway.
Gynecologic oncology - 1 Jan 2016
Chen Chi-Hau, Shyu Ming-Kwang, Wang Shu-Wei, Chou Chih-Hsing, Huang Miao-Juei, Lin Tzu-Chi, Chen Syue-Ting, Lin Ho-Hsiung, Huang Min-Chuan
Abstract excerpt
OBJECTIVE: Mucin (MUC) 20 has recently been implicated to play a role in human carcinogenesis. However, the role of MUC20 in epithelial ovarian cancer (EOC) remains to be elucidated. METHODS: MUC20 expression was assessed in tissue microarray and tumor specimens of EOC patients by immunohistochemistry. Effects of MUC20 on cell viability, adhesion, migration, and invasion were analyzed in MUC20 overexpressing or...
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